It is a potentially aggressive tumour, capable of recurring frequently, locally invasive, and with distant metastases. Moreover,squamouscellcarcinoma involving the jaws as an extension of carcinoma from either the. Vander poorten vl, balm aj, hilgers fj, tan ib, keus rb, hart aa. Clear cell odontogenic carcinoma ccoc is a rare odontogenic malignancy with a female predilection, typically presenting as swelling in.
It is potentially aggressive and capable of multiple local recurrences and locoregional and distant metastases. Clear cell odontogenic carcinoma mimicking a cystic lesion. Mandibular clear cell odontogenic carcinoma springerlink. Clear cell carcinoma ccc also known as clear cell adenocarcinoma and hyalinizing clear cell carcinomahccc is one of the rarest tumors of the minor salivary glands and infrequently occurs at the base of the tongue. Clear cell tumors of the salivary glands, jaws, and oral. Ysts can show variable presentation under a microscope, and pathologists may have difficulty in differentiating microcystic or endodermal sinuslike structures from clearcell carcinoma. Odontoameloblastoma clear cell odontogenic carcinoma keratocystic odontogenic tumour dentinogenic ghost cell tumour ghost cell odontogenic carcinoma.
Clear cell odontogenic carcinoma ccoc is a rare, lowgrade malignant epithelial neoplasm, occurring in the jawbones, mainly affecting the mandible of. Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5th7th decades and shows a female preponderance. Dentigerous cysts are one of the most common odontogenic cysts of the oral cavity. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the. Ccoc was initially known as clear cell odontogenic tumor or clear cell ameloblastoma. Clear cell odontogenic carcinoma is a rare entity that tends to arise from the body of the mandible during the fifth through seventh decades and has a female preponderance. Clear cell odontogenic carcinoma ccoc, a rare tumor in the head and neck region, displays comparable properties with other tumors clinically and pathologically. Hepatocellular carcinoma hcc is the most common primary malignancy of the liver and the third most common cause of cancerrelated deaths. Pdf odontogenic neoplasms of predominantly clear cells are unusual. Pathogenesis of ovarian clear cell adenofibroma, atypical. Two broad guiding principles are worthy of consideration for tumors that display this pattern. Rare forms were thought to occur in the gastrointestinal tract before they were discovered to be different and redesignated as gnet. The tumor was surgically excised and has not recurred or. Formerly known as clear cell odontogenic tumor, a locally aggressive benign tumor in the who classification of 1992, it was renamed ccoc and classified among malignant tumors after the revision of this classification in 2005.
Clear cell odontogenic carcinoma and clear cell variant of mucoepidermoid carcinoma are rare and aggressive tumors that usually affect individuals in the fifth decade of life and have a. Though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain. Definition of clear cell carcinoma nci dictionary of. Data set for the reporting of malignant odontogenic tumors.
Even though it was once thought to no longer occur past the age of 30, it is still seen into the 40s and 50s. Odontogenic cysts can give rise to a variety of neoplasms. Consequently, the name clear cell odontogenic carcinoma was thought to be more appropriate in view of the malignant potential manifested by this neoplastic lesion 2022. Clear cell odontogenic carcinoma ccoc is a rare neoplasm of the jaws and was first described by two separate groups of researchers, hansen et al.
Background clear cell odontogenic carcinoma ccoc, which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. Type ii papillary serous and clear cell endometrial carcinoma ec is a rare subgroup and is considered to have an unfavorable prognosis. Clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw which was first described as a clear cell odontogenic tumor in 1985 by hansen. Clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw. Clear cell carcinoma definition of clear cell carcinoma. Clear cell odontogenic carcinoma ccoc malignant epithelial odontogenic neoplasm also composed primarily of clear cells, which usually occurs in anterior mandible unlike hccc, the nests or cords may show focal palisading of basal cells ameloblastic. Clear cell odontogenic carcinomaa rare case report. The american journal of surgical pathology, 393, 338348.
A case of clear cell odontogenic tumor with unusual histological features is presented. It was then termed as clear cell odontogenic tumor considering its locally destructive nature. The objectives of this article were to present 5 additional cases and to describe the clinical course, histologic spectrum, and immunocyto. Clearcell adenocarcinoma of the vagina is a rare cancer, occurring in up to 10% of primary vaginal malignancies. Clear cell carcinoma synonyms, clear cell carcinoma pronunciation, clear cell carcinoma translation, english dictionary definition of clear cell carcinoma. Clear cell myoepithelial carcinoma of salivary glands showing ewsr1 rearrangement. Pathogenesis and nomenclature of odontogenic carcinomas. Clearcell sarcoma is a rare form of cancer called sarcoma. Clear cell odontogenic carcinoma ccoc is often considered as a rare tumor, first described by hansen in 1985. Mandibular clear cell odontogenic carcinoma ik jae kwon1, soung min kim1,2, emmanuel kofi amponsah2, hoon myoung1, jong ho lee1 and suk keun lee3 abstract background. Survival of women with clear cell and papillary serous. A 45 year old woman presented with a radiolucent left mandibular swelling associated with loss of teeth.
Strategies for classifying endometrial carcinoma with. Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5 th 7 th decades and shows a female preponderance. To our knowledge, the mr imaging appearance of this entity has not been described. Ghost cell odontogenic carcinoma gcoc was first described in detail as a malignant focus within a calcifying odontogenic cyst coc by ikemura et al. Primary clear cell carcinoma of minor salivary gland of. Here we report a case occurred in the posterior mandible of a 42 year old male patient which highlights the clinicopathologic features of ccoc that were confirmed by histopathologic. Clear cell odontogenic carcinoma ccoc, which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. Clear cell odontogenic tumor is a rare neoplasm of the jaws that histologically may be confused with metastatic renal cell carcinoma.
Also called clear cell adenocarcinoma and mesonephroma. Odontogenic tumours are rare lesions and many nonspecialist histopa. Pdf clear cell odontogenic carcinoma of the mandible. Thus, it is important to have a list of em in ones head so one doesnt misdiagnose something. Clear cell odontogenic carcinoma ghost cell odontogenic carcinoma fromodontogeniccysts. Objectives to report the clinicopathologic findings and followup. Think of that menu as a roadmap for this complete guide. Clear cell tumors of salivary gland origin are almost invariably malignant in nature but they do include two benign lesions. It is known to occur mainly in the soft tissues and dermis. In order to better elucidate the morphologic steps involved in the pathogenesis of ovarian epithelial clear cell tumors and determine whether clear cell.
Pdf clear cell odontogenic carcinoma ccoc researchgate. Clear cell odontogenic carcinoma harboring the ewsr1atf1. Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring predominantly in posterior mandible during 5th7th decades with a female predilection. Odontogenic cysts and neoplasms request pdf researchgate. You will find some basic information about this disease and the parts of the body it may affect.
Clearcell carcinoma article about clearcell carcinoma. Primary intraosseous squamous cell carcinoma arising in. Maxillary clear cell odontogenic carcinoma a rare entity. Clear cell renal cell carcinoma is a cancer of the kidney the name clear cell refers to the appearance of the cancer cells when viewed with a microscope. Clear cell odontogenic tumora new histologic variant with aggressive potential. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor of the jaws, histologically characterized by the presence of. The present report describes 2 cases of primary intraosseous squamous cell carcinoma. A case of clear cell odontogenic carcinoma of the oral cavity is described in this sine qua non radiologypathology. From 20042012 fortytwo pts with type ii ec underwent surgery followed by. A 70yearold woman presented with a large painful radiolucent mandibular lesion from the right canine to the left angle area through the midline.
A 61yearold japanese man was admitted because of swelling of the left premolarmolar region of the mandible. It was first described as a clinicopathological entity in 1985, and since then. Clear cell variant of calcifying epithelial odontogenic. It all but confirmed if maternal use of des is established. Clear cell tumours are found in a number of organs. Clear cell odontogenic carcinoma ccoc is a rare tumor of odontogenic origin. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor with predominance in the posterior mandible, usually occurring in the fifth to seventh decades of life, and being found more commonly in females. The lack of clinical and radiographic evidence of malignant disease, the absence of. About the kidneysevery person has 2 kidneys, which are located above the waist on both sides of the spine. Fulltext pdf maxillary singlejaw surgery combining le fort i and modified horseshoe osteotomies for the correction of maxillary excess.
It is potentially aggressive, capable of frequent recurrences and locoregional and distant metastases. Clear cell adenocarcinoma definition of clear cell. Pdf odontogenic tumors are a heterogeneous group of lesions of diverse clinical behavior and. Clearcell adenocarcinoma of the lung which is a type of clearcell carcinoma. Clear cell odontogenic carcinoma can be distinguished from the clear cell variant of calcifying epithelial odontogenic tumor because it lacks the characteristic calcifications and amyloid deposition. Clear cell odontogenic carcinoma ccoc, clear cell odontogenic tumor previously called clear cell ameloblastoma considered benign by who of 1992, but due to its high potential for regional spread and distant metastases, it was reclassified as malignant in 2005. The purpose of this retrospective analysis was to elucidate the meaning of adjuvant radiotherapy rt for clinical outcome and to define prognostic factors in these patients pts. Familial nonvhl clear cell renal cell carcinoma ccrcc is a hereditary condition that increases the risk of the clear cell type of renal cell carcinoma kidney cancer. The world health organization recognizes four categories of adenocarcinoma. Oral cavity clear cell odontogenic carcinoma europe pmc article.
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